108. Byrd C., Alkhamis O., Castro G., Nguyen T. & Xiao Y. (2026) High-throughput aptamer characterization via real-time nuclease digestion. J. Am. Chem. Soc.148, 10421 – 10436
107. Alkhamis O., Canoura J., Castro G., Byrd C., Bryant A., Yu H.X. & Xiao Y. (2026) Affinity maturation of a fentanyl aptamer by motif-SELEX. JACS Au, 6, 434 – 445
106. Bacon A., Alkhamis O., Byrd C., Perry J., Canoura J. & Xiao Y. (2025) Reagentless real-time ATP monitoring with new DNA aptamers. Small e08898
105. Nguyen T., Alkhamis O., Bacon A., Bukhryakov K.V., Vinueza N.R. & Xiao Y. (2025) High-contrast aptamer-based merocyanine displacement assay for sensitive small molecule detection. ACS sensors 10, 7799 – 7809
104. Alkhamis O., Byrd C., Canoura J., Bacon A., Hill R. & Xiao Y. (2025) Exploring the relationship between aptamer binding thermodynamics, affinity, and specificity. Nucleic Acids Res. 53, gkaf219
103. Yu H. X., Canoura J., Byrd C., Alkhamis O., Bacon A., Yan A., Sullenger B.A. & Xiao Y. (2025) Improving aptamer affinity and determining sequence-activity relationships via motif-SELEX. J. Am. Chem. Soc. 147, 9472 – 9486
102. Wang L.L., Canoura J., Byrd C., Nguyan T., Alkhamis O., Ly P. & Xiao Y. (2024) Examining the relationship between aptamer complexity and molecular discrimination of a low-epitope target. ACS Cent. Sci. 10, 2213 – 2228
101. Canoura J., Alkhamis O., Byrd C., Wang L.L., Bryant A. & Xiao Y. (2024) Determining the precision of high throughput sequencing and its influence on aptamer selection. Anal. Chem. 96, 17720 – 17729
100. Wang L.L., Alkhamis O., Canoura J., Yu H.X. & Xiao Y. (2024) Rapid nuclease-assisted selection of high-affinity small-molecule aptamers. J. Am. Chem. Soc. 146, 21296 – 21307
99. Canoura J., Nguyen T., Byrd C., Hill R., Liu Y.Z. & Xiao Y. (2024) Generation of high-affinity aptamers for indozole synthetic cannabinoids. Anal. Chem. 96, 11488 – 11497
98. Alkhamis O., Canoura J., Wang L.L. & Xiao Y. (2024) Nuclease-assisted selection of slow-off rate aptamers. Sci. Adv. 10, eadl3426
97. Canoura J., Alkhamis O., Venzke M., Ly P.T. & Xiao Y. (2024) Developing aptamer-based colorimetric opioid tests. JACS Au 4, 1059 – 1072
96. Yang K. Alkhamis O., Canoura J. Bryant A., Gong E.M., Barbu M., Taylor S., Nikic D., Banerjee S., Xiao Y., Stojanovic M.N. & Landry D.W. (2024) Exploring the landscape of aptamers: From cross-reactive, to selective, to specific, high-affinity receptors for cocaine. JACS Au 4, 760 – 770
95. Alkhamis O., Canoura J., Wu Y., Emmons N.A., Wang Y., Honeywell K.M., Plaxco K.W. Kippin T.E. & Xiao Y. (2024) High-affinity aptamers for in vitro and in vivo cocaine sensing. J. Am. Chem. Soc. 146, 3230 – 3240
94. Canoura J., Liu Y.Z., Alkhamis O. & Xiao Y. (2023) Aptamer-based fentanyl detection in biological fluids. Anal. Chem. 95, 18258 – 18267
93. Alkhamis O., Canoura J., Ly P.T. & Xiao Y. (2023) Using exonuclease for aptamer characterization, engineering, and sensing. Acc. Chem. Res. 56, 1731 – 1743
92. Alkhamis O., Canoura J., Willis C., Wang L.L., Perry J. & Xiao Y. (2023) Comparison of aptamer signaling mechanisms reveals disparities in sensor response and strategies to eliminate false signals. J. Am. Chem. Soc. 145, 12407 – 12422
91. Canoura J., Liu Y.Z., Perry J., Willis C. & Xiao Y. (2023) Suite of aptamer-based sensors for the detection of fentanyl and its analogs. ACS sensors 8, 1901 – 1911
90. Alkhamis O. & Xiao Y. (2023) Systematic study of in vitro selection stringency reveals how to enrich high-affinity aptamers. J. Am. Chem. Soc. 145, 194 – 206
89. Canoura J., Liu Y.Z., Alkhamis O., Willis C. & Xiao Y. (2023) High-throughput quantitative binding analysis of DNA aptamers using exonucleases. Nucleic Acids Res. 51, e19
88. Jin X., Liu Y.Z., Alkhamis O., Canoura J., Bacon A., Xu R.Y., Fu, F.F. & Xiao Y. (2022) Near-infrared dye-aptamer assay for small molecule detection in complex specimens. Anal. Chem. 94, 10082 – 10090
87. Alkhamis O., Canoura J., Bukhryakov K.V., Tarifa A., DeCaprio A.P. & Xiao Y. (2022) DNA aptamer-cyanine complexes as generic colorimetric small-molecule sensors. Angew. Chem. Int. Ed., 61, e202112305
86. Paudyal J., Wang P., Zhou F., Liu Y.Z., Cai Y. & Xiao Y. (2021) Platinum-nanoparticle-modified single-walled carbon nanotube-laden paper electrodes for electrocatalytic oxidation of methanol. ACS Appl. Nano Mater. 4, 13798 – 13806
85. Liu Y.Z., Liu X.T., Alkhamis O., Yu H.X., Canoura J. & Xiao Y. (2021) Aptamer-integrated paper electrochemical device for multi-analyte detection. ACS Appl. Mater. Interfaces. 13, 17330 – 17339
84. Liu Y.Z., Canoura J, Alkhamis O. & Xiao Y. (2021) Immobilization strategies for enhancing sensitivity of electrochemical aptamer-based sensors. ACS Appl. Mater. Interfaces. 13, 9491 – 9499
83. Yu H.X., Luo Y.P., Alkhamis O., Canoura J., Yu B.Y. & Xiao Y.(2021) Isolation of natural DNA aptamers for challenging small-molecule targets – cannabinoids. Anal. Chem. 93, 3172 – 3180
82. Yu H.X., Alkhamis O., Canoura J. and Liu Y.Z. & Xiao Y. (2021) Advances and challenges in small-molecule aptamer isolation, characterization and sensing. Angew. Chem. Int. Ed., 133, 2 – 26
81. Yu H. X., Chen Z.M., Liu Y.Z., Alkhamis O., Song Z.P. & Xiao Y. (2021) Fabrication of aptamer-modified paper electrochemical devices for on-site biosensing. Angew. Chem. Int. Ed. 60, 2993 – 3000
80. Canoura J., Yu H.X., Alkhamis O., Roncancio R., Farhana R. and Xiao Y. (2021) Accelerating post-SELEX aptamer engineering using exonuclease digestion. J. Am. Chem. Soc., 143, 805 – 816
79. Alkhamis O., Yang W.J., Farhana R., Yu H.X. and Xiao Y. (2020) Label-free profiling of DNA aptamer-small molecule binding using T5 exonuclease. Nucleic Acids Res., 48(20), e120
78. Liu Y.Z., Yu H.X., Alkhamis O., Moliver J. & Xiao Y. (2020) Tuning biosensor cross-reactivity using aptamer mixtures. Anal. Chem. 92, 5041 – 5047
77. Wu Y., Belmonte I., Sykes, K., Xiao, Y. & White R. (2019) A perspective on the future role of aptamers in analytical chemistry. Anal. Chem. 91, 15335 – 15344
76. Alkhamis O., Canoura J., Yu H.X., Liu Y.Z. & Xiao Y. (2019) Innovative engineering and sensing strategies for aptamer-based small-molecule detection. Trends Anal. Chem. 121, 115699
75. Gao H.L., Zhao, J.X., Huang Y., Cheng X., Wang S., Han Y., Xiao Y. & Lou X.H. (2019) Universal design of structure-switching aptamers with signal reporting functionality. Anal. Chem. 91, 14514 – 14521
74. Yang W.J., Yu H.X., Alkhamis O., Liu Y.Z., Canoura, J., Fu F.F. & Xiao Y. (2019) In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. Nucleic Acids Res., 47(12), e71
73. Luo Y.P., Yu H.X., Alkhamis O., Liu Y.Z., Lou X.H., Yu B.Y. & Xiao Y. (2019) Label-free, visual detection of small molecules using highly target-responsive multi-module split aptamer constructs. Anal. Chem. 91, 7199 – 7207
72. Canoura J., Wang Z.W., Yu H.X., Alkhamis O., Fu F.F. & Xiao Y. (2018) No Structure-switching required: A generalizable exonuclease-mediated aptamer-based assay for small-molecule detection. J. Am. Chem. Soc., 140, 9961 – 9971
71. Wang Z.W., Yu H.X., Canoura J., Liu Y.Z., Alkhamis O., Fu F.F. & Xiao Y. (2018) Introducing structure-switching functionality into small-molecule-binding aptamers via nuclease-directed truncation. Nucleic Acids Res., 46(13), e81
70. Yu H.X., Yang W.J., Alkhamis O., Canoura J., Yang K. & Xiao Y. (2018) In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality. Nucleic Acids Res., 46(8), e43
69. Yu H.X., Canoura J., Guntupalli B., Alkhamis O. & Xiao Y. (2018) Sensitive detection of small-molecule targets using cooperative binding split aptamers and enzyme-assisted target recycling. Anal. Chem. 90, 1748 – 1758
68. Liang P.P., Canoura J., Yu H.X., Alkhamis O. & Xiao Y. (2018) Dithiothreitol-regulated coverage of oligonucleotide-modified gold nanoparticles to achieve optimized biosensor performance. ACS Appl. Mater. Interfaces. 10, 4233 – 4242
67. Yu H.X., Xu X.W., Liang P.P., Loh K.Y., Guntupalli B., Roncancio D. & Xiao Y. (2017) A broadly-applicable assay for rapidly and accurately quantifying DNA surface coverage on diverse particles. Bioconjugate Chem., 28, 933 – 943
66. Yu H.X., Canoura J., Guntupalli B., Lou X.H. & Xiao Y. (2017) A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Chem. Sci., 8, 131 – 141
65. Xu Q., Lou X.H., Wang L., Ding X.F., Yu H.X. & Xiao Y. (2016) Rapid, surfactant-free, and quantitative functionalization of gold nanoparticles with thiolated DNA under physiological pH and its application in molecular beacon-based biosensor. ACS Appl. Mater. Interfaces. 8, 27298 – 27304
64. Guntupalli B., Liang P.P., Lee J.H., Yang Y.H., Yu H.X., Canoura J., He J., Li W.Z., Weizmann Y. & Xiao Y. (2015) Ambient filtration method to rapidly prepare highly conductive, paper-based porous gold films for electrochemical biosensing. ACS Appl. Mater. Interfaces, 7, 27049 – 27058
63. Zhao T., Liu R., Ding X.F., Zhao J.C., Yu H.X., Wang L., Xu Q., Wang X., Lou X.H., He M. & Xiao Y. (2015) Nanoprobe-enhanced, split aptamer-based electrochemical sandwich assay for ultrasensitive detection of small molecules. Anal. Chem., 87, 7712 – 7719
62. Liang P.P., Yu H.X., Guntupalli B. & Xiao Y. (2015) Paper-based device for rapid visualization of NADH based on dissolution of gold nanoparticles. ACS Appl. Mater. Interfaces, 7, 15023 – 15030
61. Roncancio D., Yu H.X., Xu X.W., Wu S., Liu R., Debord J., Lou X.H. & Xiao Y. (2014) A label-free aptamer-fluorophore assembly for rapid and specific detection of cocaine in biofluids. Anal. Chem., 86, 11100 – 11106
60. Wu S., Liang P.P., Yu H.X., Xu X.W., Liu Y., Lou X.H. & Xiao Y. (2014) Amplified single base-pair mismatch detection via aggregation of exonuclease-sheared gold nanoparticles. Anal. Chem., 86, 3461 – 3467
59. Oh S.S., Plakos K., Xiao Y., Eisenstein M. & Soh H.T. (2013) In vitro selection of shape-changing DNA nanostructures capable of binding-induced cargo release. ACS Nano, 7, 9675 – 9683
58. Lou X.H., Zhao T., Liu R., Ma J. & Xiao Y. (2013) Self-assembled DNA monolayer buffered dynamic ranges of mercuric electrochemical sensor. Anal. Chem., 85, 7574 – 7580
57. Deborggraeve S., Dai J.Y., Xiao Y. & Soh H.T. (2013) Controlling the function of DNA nanostructures with specific trigger sequences. Chem. Commun., 49, 397 – 399
56. Ahmad K.M., Xiao Y. & Soh H.T. (2012) Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution. Nucleic Acids Res., 40, 11777 – 11783
55. Feng L.Y., Zhao C.Q., Xiao Y., Wu L., Ren J.S. & Qu X.G. (2012) Electrochemical DNA three-way junction-based sensor for distinguishing chiral metallo-supramolecular complexes. Chem. Commun., 48, 6900 – 6902
54. Zuo X.L., Xia F., Patterson A., Soh H.T. Xiao Y. & Plaxco K.W. (2011) Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling. ChemBioChem, 12, 2745 – 2747
53. Olmsted I.R., Xiao Y., Cho M., Csordas A.T., Sheehan J.H, Meiler J., Soh H.T. & Bornhop D.J. (2011) Measurement of aptamer-protein interactions with back-scattering interferometry. Anal. Chem., 83, 8867 – 8870
52. Hsieh K.W., White R.J., Ferguson B.S., Plaxco K.W., Xiao Y. & Soh H.T. (2011) Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches. Angew. Chem., Int. Ed., 50, 11176 – 11180
51. Ahmad K.M., Oh S.S., Kim S., McClellen F.M., Xiao Y. & Soh H.T. (2011) Probing the limits of aptamer affinity with a microfluidic SELEX platform. PLoS ONE, 6, e27051
50. Oh S.S., Ahmad K.M., Cho M., Kim S., Xiao Y. & Soh H.T. (2011) Improving aptamer selection efficiency through volume dilution, magnetic concentration, and continuous washing in microfluidic channels. Anal. Chem., 83, 6883 – 6889
49. Ferguson B.S., Buchsbaum S.F., Wu T.T., Hsieh K.W., Xiao Y., Sun R. & Soh H.T. (2011) Genetic analysis of H1N1 influenza virus from throat swab samples in a microfluidic system for point-of-care diagnostics. J. Am. Chem. Soc., 133, 9129 – 9135
48. Wang J.P., Liu Y.L., Teesalu T., Sugahara K.N., Kotamrajua V.R., Adams J.D., Ferguson B.S., Gong Q., Oh S.S., Csordas A.T., Cho M., Ruoslahti E., Xiao Y. & Soh H.T. (2011) Selection of phage-displayed peptides on live adherent cells in microfluidic channels. Proc. Natl. Acad. Sci. U.S.A., 108, 6909 – 6914
47. Xiao Y., Dane K.Y., Uzawa T., Csordas A., Qian J.R., Soh H.T., Daugherty P.S., Lagally E.T., Heeger A.J. & Plaxco K.W. (2010) Detection of telomerase activity in high concentration of cell lysates using primer-modified gold nanoparticles. J. Am. Chem. Soc., 132, 15299 – 15307
46. Xia F., White R.J., Zuo X.L., Patterson A., Xiao Y., Kang D., Gong X., Plaxco K.W. & Heeger A.J. (2010) An electrochemical super-sandwich assay for sensitive and selective DNA detection in serum. J. Am. Chem. Soc., 132, 14346 – 14348
45. Cho M., Xiao Y., Nie J., Stewart R., Csordas A.T., Oh S.S., Thomson J.A. & Soh H.T. (2010) Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing. Proc. Natl. Acad. Sci. U.S.A., 107, 15373 – 15378
44. Oh S.S., Plakos K.J.I., Lou X.H., Xiao Y. & Soh H.T. (2010) In vitro selection of structure-switching, self-reporting aptamers. Proc. Natl. Acad. Sci. U.S.A., 107, 14053 – 14058
43. Xia F., Zuo X.L., Yang R.Q., White R.J., Xiao Y., Kang D., Gong X., Lubin A.A., Vallée-Bélisle A., Yuen J.D., Hsu B.Y.B. & Plaxco K.W. (2010) Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates. J. Am. Chem. Soc., 132, 8557 – 8559
42. Xia F., Zuo X.L., Yang R.Q., Xiao Y., Kang D., Vallée-Bélisle A., Gong X., Yuen J.D., Hsu B.Y.B., Heeger A.J. & Plaxco K.W. (2010) Colorimetric detection of DNA, small molecules, proteins and ions, using unmodified gold nanoparticles and conjugated polyelectrolytes. Proc. Natl. Acad. Sci. U.S.A., 107, 10837 – 10841
41. Hsieh K.W., Xiao Y. & Soh H.T. (2010) Electrochemical DNA detection via exonuclease and target-catalyzed transformation of surface-bound probes. Langmuir, 26, 10392 – 10396
40. Zuo X.L., Xia F., Xiao Y. & Plaxco K.W. (2010) Sensitive and selective, amplified fluorescence DNA detection based on Exonuclease III-aided target recycling. J. Am. Chem. Soc., 132, 1816 – 1818
39. Xia F., Zuo X.L., Yang R.Q., Xiao Y., Kang D., Vallée-Bélisle A., Gong X., Heeger A.J. & Plaxco K.W. (2010) On the binding of cationic, water-soluble conjugated polymer to DNA: electrostatic and hydrophobic interactions. J. Am. Chem. Soc., 132, 1252 – 1254
38. Csordas A.T., Gerdon A.E., Adams J.D., Qian J.R., Oh S.S., Xiao Y. & Soh H.T. (2010) Detection of proteins in serum via micromagnetic aptamer PCR (MAP) technology. Angew. Chem., Int. Ed., 49, 355 – 358
37. Xiao Y., Lou X.H., Uzawa T., Plakos K.J.I., Plaxco K.W. & Soh H.T. (2009) An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe. J. Am. Chem. Soc., 131, 15311 – 15316
36. Peng Y.H., Wang X.H., Xiao Y., Feng L.Y., Zhao C., Ren J.S. & Qu X.G. (2009) I-Motif quadruplex DNA-based biosensor for distinguishing single- and multiwalled carbon nanotubes. J. Am. Chem. Soc., 131, 13813 – 13818
35. Lou X.H., Xiao Y., Wang Y., Mao H.G. & Zhao J.L. (2009) Label-free colorimetric screening of nuclease activity and substrates by using unmodified gold nanoparticles. ChemBioChem, 10, 1973 – 1977
34. Oh S.S., Qian J.R., Lou X.H., Zhang Y.T., Xiao Y. & Soh H.T. (2009) Generation of highly specific aptamers via micromagnetic selection. Anal. Chem., 81, 5490 – 5495
33. Xiao Y., Uzawa T., White R.J., DeMartini D. & Plaxco K.W. (2009) On the signaling of electrochemical aptamer-based sensors: collision- and folding-based mechanisms. Electroanalysis, 21, 1267 – 1271
32. Zuo X.L., Xiao Y. & Plaxco K.W. (2009) High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices. J. Am. Chem. Soc., 131, 6944 – 6945
31. Swensen J.S., Xiao Y., Ferguson B.S., Lubin A.A., Lai R.Y., Heeger A.J., Plaxco K.W. & Soh H.T. (2009) Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic electrochemical aptamer-based sensor. J. Am. Chem. Soc., 131, 4262 – 4266
30. Lou X.H., Qian J.R., Xiao Y., Viel L., Gerdon A.E., Lagally E.T., Atzberger P., Tarasow T.M., Heeger A.J. & Soh H.T. (2009) Micromagnetic selection of aptamers in microfluidic channels. Proc. Natl. Acad. Sci. U.S.A., 106, 2989 – 2994
29. Cash K.J., Heeger A.J., Plaxco K.W. & Xiao Y. (2009) Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum. Anal. Chem., 81, 656 – 661
28. Xiao Y., Plakos K.J.I., Lou X.H., White R.J., Plaxco K.W. & Soh H.T. (2009) Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe. Angew. Chem., Int. Ed., 48, 4354 – 4358
27. White R.J., Phares N., Lubin A.A., Xiao Y. & Plaxco K.W. (2008) Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry. Langmuir, 24, 10513 – 10518
26. Xiao Y., Qu X.G., Plaxco K.W. & Heeger A.J. (2007) Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknot. J. Am. Chem. Soc., 129, 11896 – 11897
25. Xiao Y., Rowe A.A. & Plaxco K.W. (2007) Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly. J. Am. Chem. Soc., 129, 262 – 263
24. Xiao Y., Lai R.Y. & Plaxco K.W. (2007) Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing. Nat. Protoc., 2, 2875 – 2880
23. Xiao Y., Lubin A.A., Baker B.R., Plaxco K.W. & Heeger A.J. (2006) Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex. Proc. Natl. Acad. Sci. U.S.A., 103, 16677 – 16680
22. Xiao Y., Piorek B.D., Plaxco K.W. & Heeger A.J. (2005) A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement. J. Am. Chem. Soc., 127, 17990 – 17991
21. Xiao Y., Lubin A.A., Heeger A.J. & Plaxco K.W. (2005) Label-free electronic detection of thrombin in blood serum by using an aptamers-based sensor. Angew. Chem., Int. Ed., 44, 5456 – 5459
20. Xiao Y., Shlyahovsky B., Popov I., Pavlov V. & Willner I. (2005) Shape and color of Au nanoparticles follow biocatalytic processes. Langmuir, 21, 5659 – 5662
19. Xiao Y., Pavlov V., Shlyahovsky B. & Willner I. (2005) An Os-II-bisbipyridine-4-picolinic acid complex mediates the biocatalytic growth of Au nanoparticles: optical detection of glucose and acetylcholine esterase inhibition. Chem. – Eur. J., 11, 2698 – 2704
18. Pavlov V., Xiao Y. & Willner I. (2005) Inhibition of the acetycholine esterase-stimulated growth of Au nanoparticles: Nanotechnology-based sensing of nerve gases. Nano Lett., 5, 649 – 653
17. Shlyahovsky B., Katz E., Xiao Y., Pavlov V. & Willner I. (2005) Optical and electrochemical detection of NADH and of NAD+-dependent biocatalyzed processes by the catalytic deposition of copper on gold nanoparticles. Small, 1, 213 – 216
16. Pavlov V., Xiao Y., Shlyahovsky B. & Willner I. (2004) Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin. J. Am. Chem. Soc., 126, 11768 – 11769
15. Xiao Y., Pavlov V., Levine S., Niazov T., Markovitch G. & Willner I. (2004) Catalytic growth of Au nanoparticles by NAD(P)H cofactors: optical sensors for NAD(P)+-dependent biocatalyzed transformations. Angew. Chem., Int. Ed., 43, 4519 – 4522
14. Shi L.X., Xiao Y. & Willner I. (2004) Electrical contacting of glucose oxidase by DNA-templated polyaniline wires on surfaces. Electrochem. Commun., 6, 1057 – 1060
13. Niazov T., Pavlov V., Xiao Y., Gill R. & Willner I. (2004) DNAzyme-functionalized Au nanoparticles for the amplified detection of DNA or telomerase activity. Nano Lett., 4, 1683 – 1687
12. Xiao Y., Pavlov V., Niazov T., Dishon A., Kotler M. & Willner I. (2004) Catalytic beacons for the detection of DNA and telomerase activity. J. Am. Chem. Soc., 126, 7430 – 7431
11. Pavlov V., Xiao Y., Gill R., Dishon A., Kotler M. & Willner I. (2004) Amplified chemiluminescence surface detection of DNA and telomerase activity using catalytic nucleic acid labels. Anal. Chem., 76, 2152 – 2156
10. Xiao Y., Pavlov V., Gill R., Bourenko T. & Willner I. (2004) Lighting up biochemiluminescence by surface self-assembly of DNA-hemin complex. ChemBioChem, 5, 374 – 379
9. Xiao Y., Kharitonov A.B., Patolsky F., Weizmann Y. & Willner I. (2003) Electrocatalytic intercalator-induced winding of double-stranded DNA with polyaniline. Chem. Commun., 13, 1540 – 1541
8. Xiao Y., Patolsky F., Katz E., Hainfeld J.F. & Willner I. (2003) “Plugging into enzymes”: Nanowiring of redox enzymes by a gold nanoparticle. Science, 299, 1877 – 1881
7. Ju H.X., Xiao Y., Lu X.J. & Chen H.Y. (2002) Electrooxidative coupling of a toluidine blue O terminated self-assembled monolayer studied by electrochemistry and surface enhanced Raman spectroscopy. J. Electroanal. Chem., 518, 123 – 130
6. Hu X.Y, Xiao Y. & Chen H.Y. (2001) Anion adsorption on an Au colloid monolayer based cysteamine-modified gold electrode. Chem. Res. Chin. Univ., 17, 159 – 167
5. Xiao Y., Ju H.X. & Chen H.Y. (2000) Direct electrochemistry of horseradish peroxidase immobilized on a colloid/cysteamine-modified gold electrode. Anal. Biochem., 278, 22 – 28
4. Xiao Y., Ju H.X. & Chen H.Y. (1999) A reagentless hydrogen peroxide sensor based on incorporation of horseradish peroxidase in poly(thionine) film on a monolayer modified electrode. Anal. Chim. Acta, 391, 299 – 306
3. Xiao Y., Ju H.X. & Chen H.Y. (1999) Hydrogen peroxide sensor based on horseradish peroxidase-labeled Au colloids immobilized on gold electrode surface by cysteamine monolayer. Anal. Chim. Acta, 391, 73 – 82
2. Hu X.Y., Xiao Y. & Chen H.Y. (1999) Adsorption characteristics of Fe(CN)63-/4- on Au colloids as monolayer films on cysteamine-modified gold electrode. J. Electroanal. Chem., 466, 26 – 30
1. Ju H.X., Zhou D.M., Xiao Y. & Chen H.Y. (1998) Amperometric biosensor for glucose based on a nanometer-sized microband gold electrode coimmobilized with glucose oxidase and poly(o-phenylenediamide). Electroanalysis, 10, 541 – 545
Patents
21. Alkhamis O. & Xiao Y. “Method for identifying multiparatopic aptamers for cardiac troponin and usage of aptamers for detection.” 2026, patent provision
20. Wang L. & Xiao Y. “Color test for fentanyl analogs.” 2026, patent provision
19. Wang L. & Xiao Y. “Methods and compositions of aptamers for detection of low complexity molecules.” 2026, patent provision
18. Liu Y.Z., Canoura J. & Xiao Y. “Immobilization strategies for enhancing sensitivity of electrochemical aptamer-based sensors.” 2025, US12,455,256
17. Canoura J. & Xiao Y. “Compositions and methods related to aptamer-based colorimetric assays.” 2025, US20250115919A1
16. Liu Y.Z., Canoura J. & Xiao Y. “Immobilization strategies for enhancing sensitivity of electrochemical aptamer-based sensors.” 2023, US11796499B2; 2025, US12455256B2
15. Alkhamis O. & Xiao Y. “Nuclease-assisted selection of slow-off rate aptamers.” 2023, patent provision
14. Xiao Y., Alkhamis O. & Yu H.X. “DNA aptamer-cyanine complexes as mephedrone and cannabinoid colorimetric sensors.” 2023, US011656235B2
13. Canoura J. & Xiao Y. “Aptamer-based sensors for detection of fentanyl opioids.” 2023, US Patent 11579110; 2022, US Patent 11408850
12. Xiao Y. & Yu H.X. “Aptamers that bind to natural and synthetic cannabinoids.” 2021, US Patent 10907163
11. Xiao Y., Yu H.X., Canoura J. & Liu Y.Z. “Methods for generating structure-switching aptamers and uses thereof.” 2021, US patent 11162960
10. Yang W.J., Yu H.X., Liu Y.Z. & Xiao Y. “Method for isolating cross-reactive aptamer and use thereof”. 2020, US Patent 10655132, 2021, US Patent 10907162, US Patent 11060095
9. Xiao Y., Luo Y.P. & Yu H.X. “Materials and methods for colorimetric detection of small molecule targets”. 2020, US Patent 10,725,058; 2021, US 10948504
8. Xiao Y. & Yu H.X. “Materials and methods for rapid and sensitive detection of small-molecule targets”. 2020, US Patent 10550395
7. Xiao Y. & Yu H.X. “Materials and methods for rapid and specific detection of synthetic cathinones”. 2020, US Patent 10683507 and 2020, US Patent 10550395
6. Xiao Y., Guntupalli B. & Paudyal J. “Highly conductive porous paper-based metal thin films”. 2019, US Patent 10290386
5. Liang P.P., Yu H.X. & Xiao Y. “Materials and methods for rapid visualization of NAD(P)H”. 2018, US Patent 10000790
4. Roncancio D., Yu H.X., Xu X.W. & Xiao Y. “Materials and methods for rapid and specific detection of cocaine”. 2017, US Patent 9804178
3. Xiao Y., Lubin A.A. & Plaxco K.W. “Signal-on architecture for electronic, oligonucleotide-based detectors”. Patent No. US 7803542
2. Willner I., Xiao Y., Pavlov V. & Niazov T. “Catalytic polynucleotide and its use for determination of analytes”. Patent No. US 20070254282
1. Willner I., Pavlov V., Zayatz M., Niazov T., Shlyahovsky B., Xiao Y. & Buron R. “Novel sensors with nanoparticle probe”. Patent No. WO2006008742
